Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD, formerly NAFLD) affects over 30% of adults globally. A structured 7-Day Anti-Inflammatory Hepatic Nutrition Protocol targets the root metabolic drivers of hepatic steatosis: adipose tissue insulin resistance, excess dietary fructose, and gut-liver axis endotoxemia.
1. Core Nutritional Mechanisms Over 7 Days
- Soluble Prebiotic Fiber & Bile Acid Sequestration (30–35 g/day): Oats, psyllium, legumes, flaxseeds, and vegetables bind bile acids in the ileum, increasing fecal cholesterol excretion and stimulating short-chain fatty acid (butyrate) production by colonic microbiota.
- Omega-3 Polyunsaturated Fatty Acids (EPA/DHA): Downregulate hepatic sterol regulatory element-binding protein-1c (SREBP-1c) while activating peroxisome proliferator-activated receptor alpha (PPAR-α) to accelerate fatty acid oxidation.
- Choline & Betaine Sufficiency: Whole eggs, legumes, and dark leafy greens provide phosphatidylcholine precursors essential for Very-Low-Density Lipoprotein (VLDL) export of triglycerides out of hepatocytes.
Clinical Calculators & Medical Practice References:
• Liver Health, Jaundice & Hepatobiliary Clinical Guide
• Liver Function & Bilirubin Test Interpretation
• Liver Health, Jaundice & Hepatobiliary Clinical Guide
• Liver Function & Bilirubin Test Interpretation